HUANG, KENNETH HE,EAVES, JERON,VEAL, JAMES,BARTA, THOMAS,GENG, LIFENG,HINKLEY, LINDSAY,HANSON, GUNNAR
申请号：
ES06736330
公开号：
ES2527770T3
申请日:
2006.02.27
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula XXV, ** Formula ** or a pharmaceutically acceptable salt thereof, wherein R3 and R4 are independently (a) H, (b) halo or (c) a C1-C15 alkyl group wherein up to six of the carbon atoms in said alkyl group are optionally independently replaced by R22, carbonyl, ethenyl, ethynyl or a moiety selected from N, O, S, SO2 or SO, with the proviso that two O atoms, two S atoms, or an O and S 10 atom are not immediately adjacent to each other, where R22 is (i) heteroaryl, (ii) aryl, (iii) saturated or unsaturated C3-C10 cycloalkyl, or (iv) saturated C2-C10 heterocycloalkyl or unsaturated, wherein each aryl, heteroaryl, saturated or unsaturated cycloalkyl, or saturated or unsaturated heterocycloalkyl, independently, is optionally substituted with at least one group, which is independently hydroxy, halo, amino, cyano, carboxy, carboxyamide, nitro, oxo, -S-C1-C6 alkyl, -SO2-C1-C6 alkyl, -SO2-aryl, -SO- (C1-C6) alkyl, -SO-aryl, -SO2NH2, -SO2NH-(C1-C6) alkyl, -SO2NH-aryl, (C1-C6) alkoxy or mono- or di-alkylamino (C1-C10)； and each R22 is optionally condensed with a C6-C10 aryl group, saturated C5-C8 cyclic group or a C5-C10 heterocycloalkyl group； wherein each (c) is optionally substituted in any available position with C1-C10 alkyl, C1-C10 haloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, hydroxy, carboxy, carboxamido, oxo, halo, amino, cyano, nitro, -SH, -S-(C1-C6) alkyl, -SO2-(C1-C6) alkyl, -SO2NH2, -SO2NH-(C1-C6) alkyl, -SO2NH-aryl, -SO2-aryl, - SO-alkyl (C1-C6), -SO2-aryl, C1-C6 alkoxy, C2-C10 alkenyloxy, C2-C10 alkynyloxy, mono or di-alkylamino (C1-C10), -C1-C10-Z alkyl or R23, wherein Z is OR0 or -N (R30) 2, wherein each R30 is independently -H or C1-C6 alkyl, or N (R30) 2 represents pyrrolidinyl, piperidinyl, piperazinyl, azepanyl, 1,3- or 1,4-diazepanyl , or morpholinyl, each of which is optionally substituted with hydroxy, amino, aminoalkyl, C1-C6 alkyl, mono- or di-alkylamino (C1-C6), C1-C6 alkoxy or halogen； R0 is -H, -C1-C10 alkyl, -C2-C10 alkenyl, -C2-C
