The invention provides novel anti-CD27 antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer.L'invention concerne de nouveaux anticorps anti-CD27, des compositions pharmaceutiques comprenant de tels anticorps, et des procédés thérapeutiques d'utilisation de tels anticorps et compositions pharmaceutiques pour le traitement de maladies telles que le cancer.