UILLJAMS BRAJAN DZHON (UMER),УИЛЛЬЯМС Брайан Джон (умер),BERDINI VALERIO,БЕРДИНИ Валерио,KARR MARIJA GRATSIJA,КАРР Мария Грация,KONGRIV MAJLZ STJUART,КОНГРИВ Майлз Стюарт,FREDERIKSON MARTIN,ФРЕДЕРИКСО
申请号：
RU2011100786/04
公开号：
RU0002518089C2
申请日:
2009.06.12
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to novel derivatives of bicyclic heterocyclic compounds of formula (I), which can be applied in prevention or treatment of abnormal or pathological condition, mediated by FGFR kinase, such as cancer. In formula compound, (i) in case when R1 and R2 independently represent hydrogen or C3-8cycloalkyl A is group Aa, which represents aromatic group, representing phenyl R3 represents hydrogen or C1-6alkyl R4 represents group R4a, which represents amino, halogen, C1-6alkyl, -X-R5, phenyl or aromatic heterocyclic group, where said heterocyclic group represents 5- or 6-membered heterocyclyl group and contains 1, 2 or 3 heteroatoms, independently selected from nitrogen, oxygen or sulphur, where said phenyl or said heterocyclyl group can be optionally substituted with one or two Rb groups or (ii) when R1 represents hydrogen and R2 represents C1-6alkyl or halogenC1-6alkyl A is group Ab, which represents aromatic 5-membered heterocyclic group R3 represents hydrogen or C1-6alkyl R4 is group R4a, which represents halogen or (iii) when R1 represents hydrogen and R2 represents C1-6alkyl or halogenC1-6alkyl A is group Ac, which represents aromatic 6-membered heterocyclic group, containing one nitrogen atom as heteroatom R3 represents hydrogen or C1-6alkyl R4 is group R4b, which represents halogen, C1-6alkyl, -X-R5 or aromatic heterocyclic group, containing 1, 2 or 3 heteroatoms, independently selected from nitrogen, oxygen and sulphur. Other values of radicals are given in the invention formula.EFFECT: obtaining novel derivatives of bicyclic heterocyclic compounds.21 cl, 7 tbl, 250 exИзобретение относится к новым производным бициклических гетероциклических соединений формулы (I), которые могут найти применение при профилактике или лечении болезненного или патологического состояния, опосредованного FGFR киназой, такого как рак. В соединении формулы (I)(i) в случае, когда R1 и R2 независимо представляют водород или С3-8циклоалкил А являет
