The present invention provides a method for treatment or prevention of a disease associated with a decrease in bone mass comprising administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate. The present invention also provides a method of improving bone architecture and bio-mechanical strength of bone comprising administering to a subject in need of such treatment of a composition comprising an effective amount of genistein phosphate conjugate. The present invention administering to a subject in need of such treatment a composition comprising an effective amount of genistein phosphate conjugate can effectively increase the oral bioavailability so as to reduce the symptoms and the risk of complications of menopausal women, increase bone mineral content, bone density and bio-mechanical strength of bone, and slow down osteoporosis.本發明提供一種用以治療或預防與骨量(bone mass)減少相關疾病之方法，其包含：對需要此治療的使用者施用一組合物，該組合物包含一有效量之金雀異黃酮磷酸酯衍生物。本發明亦提供一種改善骨骼結構(architecture)及骨骼生物力學強度之方法，其包含：對需要此治療的使用者施用一組合物，該組合物包含一有效量之金雀異黃酮磷酸酯衍生物。本發明對需要此治療的使用者施用包含有效量之金雀異黃酮磷酸酯衍生物之組合物可有效提高口服生物可利用率，以減少更年期婦女的症狀及併發症的風險，提高骨礦物質含量、骨密度及骨骼生物力學強度，並減緩骨質疏鬆症。
