CARDINAL, JOHN R.,JAMES, JACK LAWRENCE,MELSOPP, ELSIE,OAKLEY, DAVID M.
申请号：
EP09837968
公开号：
EP2379060A4
申请日:
2009.12.18
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention provides matrix-forming, sustained-release pharmaceutical formulations comprising four primary components: i) an effective amount of at least one drug substance ii) at least one pharmaceutically acceptable, water-swellable, pH independent polymer iii) at least one pharmaceutically-acceptable, anionic, pH dependent polymer and (iv) a pharmaceutically-acceptable polymer selected from the group consisting of a) at least one pharmaceutically-acceptable cationic polymer and b) at least one pharmaceutically acceptable hydrocolloid. The present formulations can be used with compounds having a wide range of solubilities as well as compounds characterized as having hydrophobic or hydrophilic characteristics.
