CARDINAL, JOHN R.,JAMES, JACK LAWRENCE,MELSOPP, ELSIE,OAKLEY, DAVID M.
申请号：
CA2746855
公开号：
CA2746855C
申请日:
2009.12.18
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides matrix-forming, sustained-releasepharmaceutical formulations comprising four primarycomponents: i) an effective amount of at least one drug substance； ii) atleast one pharmaceutically acceptable, water-swellable,pH independent polymer； iii) at least one pharmaceutically-acceptable,anionic, pH dependent polymer； and (iv) apharmaceutically-acceptable polymer selected from the group consisting of a)at least one pharmaceutically-acceptable cationicpolymer； and b) at least one pharmaceutically acceptable hydrocolloid. Thepresent formulations can be used with compounds having awide range of solubilities as well as compounds characterized as havinghydrophobic or hydrophilic characteristics.
