METHODE D'INHIBITION DE RAS ACTIVE INTRACELLULAIRE AU MOYEN D'ANTICORPS DE TYPE IMMUNOGLOBULINE INTACT AYANT UNE CAPACITE DE PENETRATION DU CYTOSOL ET UTILISATION ASSOCIEE
KIM, YONG SUNG,CHOI, DONG KI,SHIN, SEUNG MIN,KIM, SUNG HOON
申请号：
CA2955265
公开号：
CA2955265A1
申请日:
2015.07.22
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to a method for suppressing RAS activated in a cell by using an antibody having cytoplasm penetration capacity and complete immunoglobulin form. In addition, the present invention relates to a heavy chain variable region (VH) that induces bonding, with RAS activated in a cytoplasm, by means of the active penetration, by an antibody having complete immunoglobulin form, of the cytoplasm of a living cell by endocytosis and endosomal escape, and an antibody comprising same. Also, the present invention relates to a method for treating cancer or tumors or for inhibiting the growth of cancer or tumor cells by using the antibody. The present invention also relates to a method for screening a heavy chain variable region that specifically bonds to RAS in a cytoplasm. The present invention also relates to a bioactive molecule fused to the antibody. The present invention also relates to a composition for preventing, treating or diagnosing cancer, comprising the antibody or the bioactive molecule fused to same. The present invention also relates to a polynucleotide that codes a light chain variable region and the antibody.
