ANIL KOUL,DAVID FRANCIS ALAIN LANCOIS,ISMET DORANGE,JERÔME EMILE GEORGES GUILLEMONT,KOENRAAD JOZEF LODEWIJK MARCEL ANDRIES,LEO JACOBUS JOZEF BACKX,LIEVEN MEERPOEL,MAGALI MADELEINE SIMONE MOTTE
申请号：
BRPI0612498
公开号：
BRPI0612498A8
申请日:
2006.06.26
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
use of a quinoline-derived compound, said compound, its combination, pharmaceutical composition, use of said combination, product, and process for preparing a compound. The present invention relates to the use of a compound for the manufacture of a medicament for the treatment of a bacterial infection as long as the bacterial infection is not a mycobacterial infection, said compound being a compound of formula (ia) or (ib). a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a n-oxide form thereof, wherein R1 is hydrogen, halo, haloalkyl, cyano, hydroxy ar, het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, aralkyl or di (ar) alkyl； p is 1, 2, 3 or 4； R 2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di (alkyl) amino or a radical of formula； R3 is alkyl, air, aralkyl, het or hetalkyl； q is 1, 2 or 3, R 4 and R 5 are hydrogen, alkyl or benzyl； or R 4 or R 5 are hydrogen, alkyl, or benzyl； or R 4 or R 5 together and including the node to which they are attached may form a ring； R6 is hydrogen, halo, haloalkyl, hydroxy, air, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, aralkyl or di (ar) alkyl； or two neighboring radicals may be taken together to form a bivalent radical of formula -ch = ch-ch = ch-； r is 1, 2, 3, 4 or 5； R7 is hydrogen, alkyl, ar or het； R 8 is hydrogen or alkyl； R 9 9 oxo； or r ^ 8 ^ and r ^ 9 ^ together form the radical -cn = ch-n =.uso de um composto derivado de quinolina, o referido composto, sua combinação, composição farmacêutica, uso da referida combinação, produto, e processo para preparar um composto. a presente invenção refere-se ao uso de um composto para a produção de um medicamento para o tratamento de uma infecção bacteriana contanto que a infecção bacteriana não seja uma infecção micobacteriana, o referido composto sendo um composto de fórmula (ia) ou (ib) um sal de adição de ácido ou de base fa
