您的位置: 首页 > 农业专利 > 详情页

MICROMOLDED OR 3-D PRINTED PULSATILE RELEASE VACCINE FORMULATIONS
专利权人:
Tokitae LLC;Massachusetts Institute of Technology
发明人:
Ana Jaklenec,William Gates,Philip A. Welkhoff,Boris Nikolic,Lowell L. Wood, JR.,Robert S. Langer,Thanh Duc Nguyen,Stephany Yi Tzeng,James J. Norman,Kevin McHugh
申请号:
US16401476
公开号:
US20190328871A1
申请日:
2019.05.02
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充