The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like A is lower alkylene Ring X is optionally substituted arylene E is bond or lower alkenylene Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group G is -NH-G2-, -N(lower alkyl)-G2-, -NH-CH2-G2-, -N(lower alkyl)-CH2-G2- or -CH2-G2-, wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O-R2, phenylene-G5- NH-R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O-R2, the phenylene of said phenylene-cotnaining groups being optionally substituted with one or more substituents G3-R2 is -O-lower alkylene-R2 or the like G4-O- is lower alkylene-O- or the like G5 is lower alkylene G6 is lower alkylene
