KIM, Jung Kuk,LEE, Jong Min,KIM, Sang Yun,BAE, Sung Min,JUNG, Sung Youb,KWON, Se Chang
申请号：
PE2017001168
公开号：
PE20171154A1
申请日:
2015.12.30
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to a glucose derivative, which contains a formula amino acid sequence and enhances the physical properties due to the different heteroelectric point (PL) from the local glucose: x1-x2-qgtf-x7-sds-x12-x13-x14x-x15-x16-x17-x18-x20-x21-f-x23-x24-w-l-x27-x28-t (general formula 1),Among them, X1 is histidina, desamino histidina, etc.； X2 is α - methyl gluconic acid, acido aminosobutico (AIB),X7 is trenina or valina； X12 is lysine or ethylene oxide； x13 is thyroid or ethylene oxide； x14 is leucina or ethylene oxide； x15 is acido aspartico, acido glutamic or cistina； x16 is glutamic, acido aspartico, etc.； x17 is acido aspartico, glutamine, etc.； x18 is acido aspartico, glutamina, etc； X20 is lysine, gluconic anhydride, etc.； X21 is acido aspartico, acid glucose； x23 is valina or arginina； x24 is valina, leucina, etc.； x27 is isofluorooctane or thyroxine； x28 is arginina or asparagina (provided that the amino acid sequence I in the formula is consistent with SEQ ID No.1,Not included. He also mentioned a pharmaceutical composer This derivative is useful in the treatment of obesitySe refiere a un derivado del glucagon, que comprende la secuencia de aminoacidos de formula I y que tiene propiedades fisicas mejoradas debido a un punto isoelectrico (pl) diferente a la del glucagon nativo: X1-X2-QGTF-X7-SDYS-X12-X13-X14X-X15-X16-X17-X18-X19-X20-X21-F-X23-X24-W-L-X27-X28-T (Formula General 1), donde: X1 es histidina, desamino-histidina, entre otros； X2 es acido alfa-metil-glutamico, acido aminoisobutirico (Aib), entre otros； X7 es treonina o valina； X12 es lisina o cisteina； X13 es tirosina o cisteina； X14 es leucina o cisteina； X15 es acido aspartico, acido glutamico o cisteina； X16 es acido glutamico, acido aspartico, entre otros； X17 es acido aspartico, glutamina, entre otros； X18 es acido aspartico, glutamina, entre otros； X19 es alanina o cisteina； X20 es lisina, acido glutamico, entre otros； X21 es acido aspartico, acido glutamico； X23 es valina o arginina； X24 es
