The invention provides immunogenic compositions for mucosal and parenteral applications that consist of (1) single or multiple non conjugated bacterial polysaccharide and (2) potent adjuvants. Plain polysaccharides or olygosaccharides are preferred without excluding the addition of potent adjuvants to conjugated polysaccharides. It is preferred that adjuvants were AFCox (Adjuvant Finlay Cocleate family x) or AFPLx (Proteolyposome family x). Mucosal route is preferred without excluding the parenteral one or combinations of them. The invention also provides immunogenic compositions a) a capsular sacaride antigen from serogroup C or serogroup A from Neisseria meningitidis, b) adjuvants AFPL1 adsorbed unto aluminum by parenteral route or non adsorbed AFPL1 or AFCo1 by nasal route and c) the application of two simultaneous parenteral and mucosal priming with any of the potent adjuvants formulated with the afore mentioned antigens. The use of potent adjuvants formulated with non conjugated polysaccharides enhance mucosal and systemic immune response, polarizing the independent thymus response of polysaccharides to a dependent thymus response with a pattern Th1, cellular, which ensures its functionability in young children and inducing immune memory without needing convalent conjugation.
