Instituto Finlay. Centro de Investigacion-Produccion de Sueros Y Vacunas
发明人:
Perez Martin, Oliver German,Romeu Alvarez, Belkis,Lastre Gonzalez, Miriam de San Juan Bosco,Zayas Vignier, Caridad,Gonzalez Aznar, Elizabeth,Balboa Gonzalez, Julio Antonio,Cabrera Blanco, Osmir,Cuello
申请号：
AU2012331548
公开号：
AU2012331548A1
申请日:
2012.11.02
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The invention relates to immunogenic compositions for mucosal and parenteral application, comprising (1) a single capsular saccharide or multiple unconjugated bacteria and (2) potent adjuvants. Plain oligosaccharides or polysaccharides are preferred, without excluding the addition of potent adjuvants to conjugated polysaccharides. Preferably, the adjuvants are Adjuvant Finlay Cocleato x (AFCox) or Adjuvant Finlay Proteoliposome x (AFPLx). Mucosal delivery is preferred, without excluding parenteral delivery or combinations of both. The invention also relates to immunogenic compositions (a) a capsular saccharide antigen from serogroup C or serogroup A of Neisseria meningitidis； (b) AFPL1 adjuvants absorbed in alumina by parenteral route or non-absorbed AFPL1 or AFCol by nasal route； and (c) the application of both parenteral and mucosal priming simultaneously along with any of the potent adjuvants formulated with the aforementioned antigens. The use of potent adjuvants formulated with unconjugated polysaccharides increases the systemic mucosal immune response, polarising the independent Timo response of the polysaccharides to a dependent Timo response with a Th1 cellular pattern that guarantees the function thereof in small children and induces immune memory without requiring covalent conjugation.
