Novel substituted carbonyl compounds represented by general formula (I) or salts thereof, which exhibit excellent bronchodilating effect that relies on potent EP2 agonist activity and which are useful in the treatment of respiratory diseases. In general formula (I), R is -OR, -O(CHCHO)R or -NRR (wherein R is C alkyl or the like； R is H or benzyl； m is 1 to 4； and R and R are each H, C alkyl, or the like)； R and R are each H or C alkyl； Y is a (substituted) bicyclic heteroaromatic ring, -Q-Q, or the like (wherein Q is arylene or the like； and Q is a (substituted) 5- or 6-memebred heterocycle, or the like)； and Z is (substituted) aryl or a (substituted) 5- or 6-memeberd heteroaromatic ring.
