The application relates to a prosthesis of the anterior spinal column, which consists of a perforated sleeve body provided with at least one anchoring element, teeth and overgrowth holes and a positioner (2) situated within the body (1). The body has got in its wall at least one through manipulative hole (6) and at least one through positioning hole (7) cooperating with it, whose longitudinal axes are parallel with each other, whereas the positioner is provided with at least one situating element (8) cooperating with at least one positioning hole of the body and at least one hole (12), where the length of the manipulative hole of the body corresponds to the distance between extreme locations of the positioners hole situated within the inside diameter of the manipulative hole. At least one end face (3) of the body or/and bodys wall are provided with at least one pair of opposite guidelines (14). For introducing the prosthesis into the intervertebral space a guiding instrument is used in the form of a rod ended from one side with a holder and from the other side with a shaped working element. The application relates also to the method of implantation of the prosthesis with the use of the prosthesis guiding instrument.
