A prosthesis of an anterior spinal column, comprising a perforated sleeve body (1) with at least one anchoring element, teeth and overgrowth holes and a positioner (2) situated within the body (1). The body (1) has in its wall at least one manipulative hole (6) and at least one positioning hole (7), whose longitudinal axes are parallel with each other. The positioner (2) comprises at least one situating element (8) cooperating with at least one positioning hole (7) of the body (1) and at least one hole (12) formed therethrough, which may be situated radially inward relative to the manipulative hole (6). At least one end face (3) of the body (1) or/and body's wall are provided with at least one pair of opposite guidelines (14,20). For introducing the prosthesis into the intervertebral space, a guiding instrument is used in the form of a rod with a shaped working element (24) at one end. The prosthesis may be implanted with the use of the prosthesis guiding instrument.
