Disclosed is an isolated monoclonal antibody, or a divalent functional fragment or derivative thereof, capable to inhibit the c-Met dimerization, said antibody comprising a heavy chain comprising CDR-H1, CDR-H2 and CDR-H3 with respectively 5 the amino acid sequences SEQ ID Nos. 1, 2 and 3 and a light chain comprising CDR-L1, CDR-L2 and CDR-L3 with respectively the amino acid sequences SEQ ID Nos. 5, 6 and 7, wherein said antibody comprises a hinge region comprising an amino acid sequence selected from the group consisting of SEQ ID Nos. 59 to 63 and 66 to 70.
