compound, method for inhibiting pak1 activity in a cell and patient, method for treating or improving the severity of cancer or a hyperproliferative disorder in a patient, use of the compound and composition

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专利权人:

F.HOFFMANN-LA ROCHE AG

发明人:

IGNACIO ALIAGAS-MARTIN,JAMES CRAWFORD,JOACHIM RUDOLPH,SIMON MATHIEU,WENDY LEE

申请号：

BR112014003997

公开号：

BR112014003997A2

申请日:

2012.08.24

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

Compounds having the formula I wherein A, Z, R1a, R1b, R2, R3, R4, R5, R6, R7, R9, R10, Ra, Rb and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.

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