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Adagolási forma nehezített/gátolt visszaélési lehetõséggel
专利权人:
Gruenenthal GmbH
发明人:
ARKENAU-MARIC, Elisabeth,BARTHOLOMÄUS, Johannes,ZIEGLER, Iris,HAUPTS, Marcel
申请号:
HUE08716192
公开号:
HUE033554T2
申请日:
2008.03.03
申请国别(地区):
HU
年份:
2017
代理人:
摘要:
A multiparticulate dosage form formulated to make misuse more difficult containing least one active substance with potential for misuse (A), at least one synthetic or natural polymer (C), optionally at least one natural, semi-synthetic or synthetic wax (D), at least one disintegrant (E) and optionally one or more additional physiologically compatible excipients (B), wherein the individual particles of the dosage form display a breaking strength of at least 500 N and a release of active substance of at least 75% after 45 minutes measured according to Ph.Eur. in the paddle mixer with sinker in 600 ml of aqueous buffer solution with a pH value of 1.2 at 37° C. and 75 rpm.
来源网站:
中国工程科技知识中心
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