Johannes Bartholomaeus;Iris Ziegler;Elisabeth Arkenau-Marić;Marcel Haupts
发明人:
Elisabeth Arkenau-Marić,Johannes Bartholomaeus,Iris Ziegler,Marcel Haupts
申请号：
US12044586
公开号：
US08722086B2
申请日:
2008.03.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A multiparticulate dosage form formulated to make misuse more difficult containing least one active substance with potential for misuse (A), at least one synthetic or natural polymer (C), optionally at least one natural, semi-synthetic or synthetic wax (D), at least one disintegrant (E) and optionally one or more additional physiologically compatible excipients (B), wherein the individual particles of the dosage form display a breaking strength of at least 500 N and a release of active substance of at least 75% after 45 minutes measured according to Ph.Eur. in the paddle mixer with sinker in 600 ml of aqueous buffer solution with a pH value of 1.2 at 37° C. and 75 rpm.
