An elastic physiological patch (100, 100', 100", 100a, 100b, 100c) includes a patch assembly (2) and an implant assembly (3). The patch assembly (2) includes an electronic device (4), and a soft patch body (5) defining a chamber (53) for receiving the electronic device (4). The implant assembly (3) is mountable to the electronic device (4) and includes an implant (31) which is capable of being driven to partially pass through the patch body (5) and which is adapted to be implanted in the skin of a subject. The implant (31) and the patch body (5) cooperatively seal the chamber (53).