PROCEDE POUR ELIMINER UNE HEMOGLOBINE NON MODIFIEE DE SOLUTIONS D'HEMOGLOBINE RETICULEE CONTENANT UNE HEMOGLOBINE POLYMERE AVEC UN APPAREIL DE TRAITEMENT THERMIQUE DE COURTE DUREE A HAUTE TEMPERATURE
A method heat treatment of cross-linked hemoglobin solutions including polymeric hemoglobin is disclosed. The method involves contacting the hemoglobin solution with a high temperature short time heat treatment apparatus. The high temperature short time process thermally denatures unmodified tetrameric hemoglobin (hemoglobin dimer form), protein impurities (e.g. immunoglobin-G, serum albumin), bacteria, and viruses so that renal injury, vascular detrimental effects and other toxicity reactions can be avoided.
