EIDAM, HILARY SCHENCK,DEMARTINO, MICHAEL P.,GONG, ZHEN,GUAN, AMY HUIPING,RAHA, KAUSHIK,WU, CHENGDE,YANG, HAIYING,YU, HAIYU,ZHANG, ZHILIU,CHEUNG, MUI
申请号：
PE0018782015
公开号：
PE15382015A1
申请日:
2014.03.14
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Refers to a compound according to formula (i), which are inhibitors of the kinase RET, useful for treating proliferative diseases, Functional disorders, etc, wherein: R1 is Hydrogen, halogen, etc R2 C1 - C6 is Halogen, alkyl, etc. R3 is phenyl, etc n is 0, 1 or 2.Preferred compounds are: 2 - (4 - (5 - ethoxy - 3 - oxo - 1.6 - dihidropiridin - 3 - yl) - 2-fluorophenyl) - N - (4 - (2 - hidroxipropan - 2 - yl) - 5 - (trifluoromethyl) pyridin-3-yl) acetamide, N - (6 - ethoxy - 5 - (trifluoromethyl) pyridin-3-yl) 2 - (4 - (5 - ethoxy - 3 - oxo - 1.6 - dihidropiridin - 3 - yl) - 2-fluorophenyl) acetamide, among othersSe refiere a un compuesto de acuerdo con la formula (I), los cuales son inhibidores de la quinasa RET, utiles para tratar enfermedades proliferativas, trastornos funcionales, etc, en donde: R1 es hidrogeno, halogeno, etc R2 es halogeno, alquilo C1-C6, etc R3 es fenilo, etc n es 0, 1 o 2. Son compuestos preferidos: 2-(4-(5-etoxi-6-oxo-1,6-dihidropiridin-3-il)-2-fluorofenil)-N-(6-(2-hidroxipropan-2-il)-5-(trifluorometil)piridin-3-il)acetamida, N-(6-etoxi-5-(trifluorometil)piridin-3-il)2-(4-(5-etoxi-6-oxo-1,6-dihidropiridin-3-il)-2-fluorofenil)acetamida, entre otros
