The present disclosure relates to the field of food and/or drug technology. Disclosed is a blood lipid-lowering composition, method for preparing the same and use thereof. The blood lipid-lowering composition comprises echium seed oil, camelina seed oil and safflower seed oil. The specific natural substances echium seed oil, camelina seed oil and safflower seed oil are used as the functional ingredients to form a natural composition that can significantly reduce the total cholesterol and triglyceride levels and increase the content of the serum apolipoprotein A1, having an obvious blood lipid-lowering function, which may be used in developing and preparing blood lipid-lowering drugs and foods, especially health care foods.