ЛАМБЕН Филипп (BE),ВИНЭМ Жан-Ив (FR),СУПУРАН Клаудиу (IT)
申请号：
RU2013134480/04
公开号：
RU2013134480A
申请日:
2011.12.21
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A compound represented by formula (1): wherein Z represents Z1 of the formula (2a): or Z represents Z2 of the formula (2b): (CH) CHX, or Z represents Z3 of formula (2c): and R1 and R2 each independently may be H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic group, aryl group, cyano group or halogen atom, R3, R4, R6 and R7 each independently can represent H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic group, aryl, halogen, cyano, alkoxy, sulfonamide, sulfamate or sulfamide, R5 may represent GSS minutes sulfonamide, sulfamate or sulfamide, X = sulfonamide, sulfamate or sulfamide, Y = O or S, and n = 0, 1, 2, 3, 4 or 5, and wherein when n = 0, R2 = 2-CH, Z = Z1, R3 = R4 = R6 = R7 = H and R5 = SONH, the NOnahoditsya not in the 4-position, and pharmaceutically acceptable soli.2. The compound of claim 1 having the formula (3a) formula (3b) or formula (3c) and R1 and R2 each independently may be H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic group, aryl group, cyano group or halogen atom, R3 , R4, R6 and R7 each independently can be H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic group, aryl, halogen, cyano, alkoxy, sulfonamide, sulfamate or sulfamide, R5 may be a sulfonamide, sulfamate or sulfamide, X = sulfonamide, sulfamate or sulfamide, Y = O or S, n = 0, 1, 2, 3, 4 or 5, and pharmaceutically acceptable soli.3. A compound according to claim 1, wherein R1 and R2 are each independently H or CH.4. A compound according to claim 1, wherein Rl = R2 = H.5. A compound according to claim 1, wherein R3 = R4 = R7.6. A compound according to claim 1, wherein R3 = R4 = R7 = H.7. A compound according to claims 1-6, wherein R5 or R6 represents sulfonamid.8. A compound according to claim 7, wherein R5 = sulfonamid.9. join1. Соединение, представленное формулой (1):где Z представляет собой Z1 с формулой (2a):или Z представляет собой Z2 с формулой (2b): (CH2)nCH2X,или Z представляет собой Z3 с формулой (2c):и R1 и R2 каждый независимо может представлять собой H, а
