ИЛЛСУОРТ Брюс (US),УОШБУРН Уилльям Н. (US),ШЕР Филип М. (US),ВУ Ганг (US),МЕНГ Вей (US)
申请号：
RU2013115635/15
公开号：
RU2013115635A
申请日:
2013.04.08
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method for treating or slowing the progression or onset of diabetes, diabetic retinopathy, diabetic neuropathy, diabetic nephropathy, slow healing of wounds, insulin resistance, hyperglycemia, hyperinsulinemia, elevated levels of fatty acids or glycerol in the blood, hyperlipidemia, obesity, hypertriglyceridemia, Syndrome, Syndrome diabetes, atherosclerosis or hypertension, or an increase in blood levels of high density lipoproteins, including the administration to mammals in need of treatment, therapeutic and an effective amount of a compound having the structure or a pharmaceutically acceptable salt, stereoisomer or ester constituting prolekarstvo.2. The method of claim 1, wherein the compound has a structure. A method for treating type 2 diabetes, comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound having a structure, or a pharmaceutically acceptable salt, stereoisomer or ester thereof, which is a prodrug, alone or in combination with another antidiabetic agent, an agent for treating diabetes complications, an anti-obesity agent, antihypertensive agent, anti-platelet agent, anti-atherosclerotic agent and / or lipid-lowering agent .4. The method of claim 3, wherein the compound is administered separately. The method of claim 3, wherein the compound is administered in combination with another antidiabetic agent. The method according to claim 5, wherein the antidiabetic agent is 1, 2, 3 or more of biguanide, sulfonylurea, glucosidase inhibitor, PRAR γ agonist, PRAR α / γ double1. Способ лечения или замедления прогрессирования или начала диабета, диабетической ретинопатии, диабетической нейропатии, диабетической нефропатии, медленного заживления ран, инсулиновой резистентности, гипергликемии, гиперинсулинемии, повышенных уровней жирных кислот или глицерина в крови, гиперлипидемии, ожирения, гипертриглицеридемии, Синдрома X, осложнений диабета, атеросклероза или гипертензии, или повышения в крови уровней липо
