As for this invention, being use of the additive in order to be stabilized the hyaluronic acid which is blendinged in the water solution, vis-a-vis the disintegration of enzyme such as heat or hyaluronidase, the aforementioned additive, the molecular weight of 20,000 Dalton or more and at least 1g/l or includes 1 genera or the multiple polysaccharides which possess the water solubility which exceeds that, the aforementioned polysaccharide in the constituent (multiple yeses) and entire concentration of hyaluronic acid, as for this inside the especially human or the joint for the animal, intradermal or is ideal in dosage inside the eyeball in regard to the use which features that at least the viscosity of 500cP is given to the constituent.本発明は、水性溶液中に配合されたヒアルロン酸を、熱またはヒアルロニダーゼなどの酵素の分解作用に対して安定化するための添加剤の使用であって、前記添加剤が、20,000ダルトン以上の分子量および少なくとも1g/lまたはそれを超える水溶性を有する1種または複数の多糖を含み、組成物中の前記多糖(複数可)およびヒアルロン酸の総濃度が、組成物に少なくとも500cPの粘度を与えることを特徴とする使用に関し、これは特に人間または動物に対する関節内、皮内または眼球内投与に好適である。
