Tilo Knape,Andreas Von Knethen,Michael John Parnham,Manfred Schubert-Zsilavecz,Mario Wurglics,Daniel Flesch
申请号：
US15500330
公开号：
US10093628B2
申请日:
2015.07.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention pertains to a new compound E)-2-(5-((4-methoxy-2-(trifluoromethyl)quinolin-6-yl)methoxy)-2-((4-(trifluoromethyl) benzyl)oxy)-benzylidene) hexanoic acid (MTTB), and its derivatives. The compounds of the invention are useful as selective peroxisome proliferator-activated receptor gamma (PPARγ) antagonists and are indicated for the use in the treatment of immune related diseases such as systemic inflammation, sepsis and septic shock.
