FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
发明人:
KNAPE, TILO,VON KNETHEN, ANDREAS,PARNHAM, MICHAEL JOHN,SCHUBERT-ZSILAVECZ, MANFRED,WURGLICS, MARIO,FLESCH, DANIEL
申请号：
CA2956854
公开号：
CA2956854A1
申请日:
2015.07.14
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention pertains to a new compound E)-2-(5-((4-methoxy-2- (trifluoromethyl)quinolin-6-yl)methoxy)-2-((4-(trifluoromethyl) benzyl)oxy)-benzylidene) hexanoic acid (MTTB), and its derivatives. The compounds of the invention are useful as selective peroxisome proliferator-activated receptor gamma (PPAR) antagonists and are indicated for the use in the treatment of immune related diseases such as systemic inflammation, sepsis and septic shock.
