Fei Huang,Xia Han,Rameh Hafezi,Jiwen Chen,Douglas Michael Robinson,Gayle M. Wittenberg,Ashok Ramesh Dongre,Joan M. Carboni,Ricardo M. Attar,Warren Hurlburt,Marco M. Gottardis
申请号：
US12600504
公开号：
US08492328B2
申请日:
2008.05.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
IGF1R biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an IGF1R modulator, wherein the method comprises (a) exposing the mammal to the IGF1R modulator and (b) measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in (b) compared to the level of the biomarker in a mammal that has not been exposed to the IGF1R modulator indicates that the mammal will respond therapeutically to the method of treating cancer and (c) wherein the level of the biomarker in a mammal after exposure to a IGF1R modulator indicates that the mammal has responded therapeutically to the method of treating cancer.
