A tissue grasping device includes a longitudinal axis member an actuating member provided at a distal end portion of the longitudinal axis member a wire member elongated to an outside of the actuating member and being curved in a loop shape a through hole formed in a distal end surface of the actuating member and holding a first end side of the wire member such that the first end side of the wire member is capable of moving with respect to the actuating member and a direction restriction portion provided at a side surface of the actuating member and fixing a second end portion of the wire member to the actuating member such that an elongated direction of a second end side of the wire member is coincide with a direction intersecting a side surface of the actuating member.
