KÜHNERT SVEN,BAHRENBERG GREGOR,KLESS ACHIM,SCHRÖDER WOLFGANG
申请号：
NZ60869711
公开号：
NZ608697A
申请日:
2011.08.26
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
This disclosure relates to a family of 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides with a varied amount of substitution off the quinoline frame. The frame is characterised by either a sulfur or oxygen atom at the two position and an amide bond at the three position that can be substituted further. The disclosure also relates to pharmaceutical compositions containing these compounds and a method of treatment and/or prophylaxis of pain, epilepsy, urinary incontinence, anxiety, dependency, mania, bipolar disorders, migraine and cognitive diseases, which are all mediated, at least in part, by KCNQ2/3 K+ channels., Example compounds include:, 7-Cyano-N-[(3-fluorophenyl)-methyl]-1,4-dimethyl-2-oxo-1H-quinoline-3-carboxylic acid amide, 7-Cyano-N-[(4-fluorophenyl)-methyl]-1,4-dimethyl-2-oxo-1H-quinoline-3-carboxylic acid amide, 7-Cyano-N-[(3-fluorophenyl)-methyl]-1-(2-methoxy-ethyl)-4-methyl-2-oxo-1H-quinoline-3-carboxylic acid amide, 7-Cyano-N-[(4-fluorophenyl)-methyl]-1-(2-methoxy-ethyl)-4-methyl-2-oxo-1H-quinoline-3-carboxylic acid amide, N-(4,4-Dimethyl-pentyl)-1-(2-methoxy-ethyl)-4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide, N-(4,4-Dimethyl-pentyl)-1,4-dimethyl-2-oxo-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide, 2-[3-[(3-Fluorophenyl)-methyl-carbamoyl]-4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinolin-1-yl]-acetic acid methyl ester, 3-[3-[(3-Fluorophenyl)-methyl-carbamoyl]-4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinolin-1-yl]-propionic acid methyl ester, 2-[3-[(3-Fluorophenyl)-methyl-carbamoyl]-4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinolin-1-yl]-acetic acid, 3-[3-[(3-Fluorophenyl)-methyl-carbamoyl]-4-methyl-2-oxo-7-(trifluoromethyl)-1H-quinolin-1 -yl]-propionic acid.
