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BIOCIDAL PEPTIDE AND PREPARATION BASED THEREON
专利权人:
"VERTA RESEARCH-PRODUCTION COMPANY" LTD
发明人:
Irina Vasil'evna AFONINA,Alexandr Alexandrovich KOLOBOV,Nikolay Ivanovich KOLODKIN,Mariya Pavlovna SMIRNOVA,Ludmila Ivanovna STEFANENKO
申请号:
US16483879
公开号:
US20200071358A1
申请日:
2018.01.29
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The invention relates to the field of medicine, in particular to novel peptides having biocidal properties, more particularly antibacterial, antifungal and antiviral properties, and preparations based thereon. Proposed are a biocidal peptide of general formula Y-Ile-Leu-Pro-X-Lys-X-Pro-X-X-Pro-X-Arg-Arg-NH2, where X is 4-nitrophenylalanine; 4-chlorophenylalanine; 4-methoxyphenylalanine; D-phenylalanine; 4-aminophenylalanine; 4-aminobenzoylphenylalanine; homophenylalanine; 4-tertbutylphenylalanine; 2-methylphenylalanine; 4-fluorophenyl alanine; pentafluorophenylalanine; or 2-trifluoromethylphenylalanine; and Y is H or palmitoyl or aminodecanoyl, and a preparation in the form of a gel with biocidal properties, containing, as an active substance, said peptide at a concentration of 0.001 to 0.1 wt %. The claimed peptides demonstrate biocidal properties towards bacteria, including spore-forming bacteria, mould fungi, and also viruses. The peptide-based gels can be used for treating bacterial and viral infectious diseases and infectious comorbidities.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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