A multiple hemostatic clip application apparatus operates for tissue clamping in combination with an endoscope. For use with the clip application apparatus, a clip package is provided, and has a multiple clip assembly, which includes a clip device, and a fastening mechanism, disposed at a proximal end of the clip device, for fastening to a shaft head of an operating wire inserted through a flexible sheath of the clip application apparatus. A coupling device includes a casing for containing the multiple clip assembly in a manner movable from the fastening mechanism toward the flexible sheath, and a guide slider for pressing the shaft head toward the fastening mechanism, for fastening together. The fastening mechanism emerges from the casing, the shaft head being overlapped on the fastening mechanism in an axial direction of the multiple clip assembly.
