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The novel process for preparing ginkgo extracts
专利权人:
イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ
发明人:
ベン-プーン・テン,ベン-プーン・テン
申请号:
JP2010545526
公开号:
JP5710271B2
申请日:
2009.02.06
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
Preparing an extract comprises (a) extracting Ginkgo bilobaleaves with e.g. aqueous acetone; (b) separating major part of the organic solvent from the extract; (c) diluting the remaining concentrated aqueous solution with water; (d) adding ammonium sulfate to the remaining aqueous solution and extracting the formed solution with methylethylketone; (e) concentrating the obtained extract; (f) adding an aqueous solution of a lead salt to the obtained solution; and (g) extracting the remaining aqueous alcoholic solution with an aliphatic or cyclophatic solvent. Preparing an extract of Ginkgo bilobaleaves, comprises (a) extracting Ginkgo bilobaleaves at a temperature of approximately 40-100[deg] C, with aqueous acetone, 1-3C aqueous alcohol or anhydrous methanol; (b) separating major part of the organic solvent from the extract containing up to 10 wt.%, so that the water is added during final stages of distillation; (c) diluting the remaining concentrated aqueous solution with water to obtain a content of solid materials of 5-25 wt.%, allowing to cool by stirring, at a temperature of below25[deg] C, until to form a precipitate, where the resulting precipitate comprises lipophilic components, which does not dissolve well in water, and is separated; (d) adding ammonium sulfate to the remaining aqueous solution and extracting the formed solution with a methylethylketone or a mixture of methylethylketone and acetone; (e) concentrating the obtained extract to a solid material content of 50-70% and diluting the obtained concentrate diluted with water and ethanol to obtain a solution containing 50 wt.% of water and 50 wt.% of ethanol with a content of solid materials of 10 wt.%; (f) adding an aqueous solution of a lead salt to the obtained solution until a change in the brown color to amber color occurs, and separating the formed precipitate, in which a polyamide is used instead of a lead salt; (g) extracting the remaining aqueous alcoholic solution with an aliphatic or cycloph
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