ANDRES-GIL, JOSÉ IGNACIO,ALCAZAR-VACA, MANUEL JESÚS,DAUTZENBERG, FRANK MATTHIAS,LINDERS, JOANNES THEODORUS MARIA
申请号：
ES07847809
公开号：
ES2483866T3
申请日:
2007.12.04
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound according to formula (I) a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, in which: A is a radical according to formula (II ) in which k, l, m, n are each independently of each other, an integer equal to 0, 1, 2, 3 or 4, with the proviso that (k + l) and (m + n) are equal to 2, 3, 4 or 5； in which one of the remains -CH2- can be replaced by O； and in which each of the moieties -CH2- can be substituted with oxo； X is CH or N； R3 is selected from the group of hydrogen, C1-5 alkyl, C3-6 cycloalkyl and C1-5 alkyloxycarbonyl； R4, R5 are each independently selected from the group of hydrogen, halo, cyano, hydroxyl, amino, oxo, carboxyl, nitro, thio, formyl, C1-3 alkyl and C1-3 alkyloxy； p is an integer, equal to zero, 1, 2 or 3； q is an integer, equal to zero, 1, 2 or 3； Y1, Y3 are each independently selected from the group of a single link, O, NR7, S, SO and SO2； wherein R7 is selected from the group of hydrogen and C1-3 alkyl； Y2 is a saturated or unsaturated, linear or branched C1-6 hydrocarbon radical, in which one or more hydrogen atoms may optionally be replaced by a radical selected from the group of halo, cyano, hydroxyl, amino, oxo, carboxyl, nitro, thio and formyl； B is a 6-membered ring containing zero, 1, 2 or 3 nitrogen atoms, optionally substituted with r R6 substituents selected, each independently from each other, from the group of halo, cyano, hydroxyl, amino, oxo, carboxyl, nitro , thio, formyl, C1-3 alkyl and C1-3 alkyloxy； and in which r is an integer, equal to 1 or 2； or two R6 substituents can be combined to give a radical -CH2CH2CH2- or -OCH2O-； alkyl is a saturated linear or branched hydrocarbon radical having the indicated number of carbon atoms； wherein the radical may be optionally substituted at one or more carbon atoms with one or more radicals selected from the group of halo, cyano, hydroxyl, amino, oxo, carboxyl, nitro, thio and formyl； and halo is fluor
