PROBLEM TO BE SOLVED: To provide a medicine that skips a 53rd exon of a human dystrophin gene highly efficiently.SOLUTION: An antisense oligomer consists of a base sequence complementary to any one of sequences consisting of 31st to 53rd, 31st to 54th, 31st to 55th, 31st to 56 th, 31st to 57th, 31st to 58th, 32nd to 53rd, 32nd to 54th, 32nd to 55th, 32nd to 56th, 32nd to 57th, 32nd to 58th, 33rd to 53rd, 33rd to 54th, 33rd to 55th, 33rd to 56th, 33rd to 57th, 33rd to 58th, 34th to 53rd, 34th to 54th, 34th to 55th, 34th to 56th, 34th to 57th, 34th to 58th, 35th to 53rd, 35th to 54th, 35th to 55th, 35th to 56th, 35th to 57th nucleotides or other nucleotides from a 5 terminal of a 53rd exon of a human dystrophin gene.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】ヒトジストロフィン遺伝子の第53番目のエクソンを高効率にスキッピングさせる薬剤の提供。【解決手段】ヒトジストロフィン遺伝子の第53番目のエクソンの5’末端から第31~53番目、第31~54番目、第31~55番目、第31~56番目、第31~57番目、第31~58番目、第32~53番目、第32~54番目、第32~55番目、第32~56番目、第32~57番目、第32~58番目、第33~53番目、第33~54番目、第33~55番目、第33~56番目、第33~57番目、第33~58番目、第34~53番目、第34~54番目、第34~55番目、第34~56番目、第34~57番目、第34~58番目、第35~53番目、第35~54番目、第35~55番目、第35~56番目、第35~57番目、などのヌクレオチドからなる配列のいずれか1つに相補的な塩基配列からなる、アンチセンスオリゴマー。【選択図】なし
