#$%^&*AU2012202085A120120503.pdf#####ABSTRACT Conserved consensus sequences from known hepatitis B virus strains and known hepatitis C virus strains, which are useful in inhibiting the expression of the viruses in 5 mammalian cells, are provided. These sequences are useful to silence the genes of HBV and HCV, thereby providing therapeutic utility against HBV and HCV viral infection in humans.1/16 T7 Promoter Transcription unit encoding SEQ ID NO:1 hairpin FIG. 1 T7 Terminator T7 Terminator T7 Promoter Transcription unit encoding SEQ ID NO:11 hairpin FIG. 2 3.5 3 2.5 2 -+-pHBV2 15 -- 2791(0.5) 0.5 0 0 2 4 6 8 10 12
