BRAHMBHATT HIMANSHU,MACDIARMID JENNIFER,BRAHMBHATT Himanshu,MACDIARMID Jennifer
申请号：
SI200531990
公开号：
SI1718338T1
申请日:
2005.01.27
申请国别(地区):
SI
年份:
2015
代理人:
摘要：
A composition comprising intact minicells that contain a drug molecule is useful for targeted drug delivery. One targeted drug delivery method employs bispecific ligands, comprising a first arm that carries specificity for a bacterially derived minicell surface structure and a second arm that carries specificity for a mammalian cell surface receptor, to target drug-loaded minicells to specific mammalian cells and to cause endocytosis of the minicells by the mammalian cells. Another drug delivery method exploits the natural ability of phagocytic mammalian cells to engulf minicells without the use of bispecific ligands.
