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Usmerjeno dovajanje zdravil, terapevtskih nukleinskih kislin in funkcionalnih nukleinskih kislin v sesalske celice preko intaktnih pokončanih bakterijskih celic
专利权人:
EnGeneIC Molecular Delivery Pty Ltd.
发明人:
BRAHMBHATT Himanshu,MACDIARMID Jennifer
申请号:
SI200731883
公开号:
SI2712618T1
申请日:
2007.06.20
申请国别(地区):
SI
年份:
2017
代理人:
摘要:
A composition comprising intact killed bacterial cells that contain a therapeutic nucleic acid, a drug or a functional nucleic acid is useful for targeted delivery to mammalian cells. The targeted delivery optionally employs bispecific ligands, comprising a first arm that carries specificity for a killed bacterial cell surface structure and a second arm that carries specificity for a mammalian cell surface receptor, to target killed bacterial cells to specific mammalian cells and to cause endocytosis of the killed bacterial cells by the mammalian cells. Alternatively, the delivery method exploits the natural ability of phagocytic mammalian cells to engulf killed bacterial cells without the use of bispecific ligands.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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