Modified plant defensins useful as anti-pathogenic agents

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专利权人:

HEXIMA LIMITED

发明人:

VAN DER WEERDEN NICOLE,ANDERSON MARILYN ANNE

申请号：

NZ61343312

公开号：

NZ613433A

申请日:

2012.02.07

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Disclosed is an isolated artificially modified solanaceous Class II defensin polypeptide with a loop region (Loop 1B) between a first Beta-strand and an Alpha-helix at its N-terminal end portion and having anti-fungal activity, and wherein said Loop 1B is replaced by an exogenous Loop 1B amino acid sequence, said polypeptide having at least 70% similarity to SEQ ID NO:52 after optimal alignment； wherein SEQ ID NO: 52 is as disclosed in the specification.

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