International Institute of Cancer Immunology; Inc.
发明人:
Haruo Sugiyama,Fumihiro Fujiki
申请号：
US14427465
公开号：
US20160009781A1
申请日:
2013.09.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention pertains to polynucleotides that encode CDR3 in TCR-[alpha] and TCR-[beta] chain genes of CD4+ helper T-cells that are specific to WT1 helper peptides having an amino acid sequence represented by SEQ ID NO: 123. The present invention further pertains to the peptides encoded by said polynucleotides. The present invention further pertains to CD4+ T cells into which TCR genes that contain said polynucleotides have been introduced, the induction of WT1-specific cytotoxic T-lymphocytes (CTLs) using the CD4+ T-cells, the treatment of cancer, etc.
