INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY; INC.
发明人:
SUGIYAMA, HARUO,FUJIKI, FUMIHIRO
申请号：
CA2884366
公开号：
CA2884366A1
申请日:
2013.09.12
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention pertains to polynucleotides that encode CDR3 in TCR-a and TCR-ß chain genes of CD4+ helper T cells that are specific to WT1 helper peptides having an amino acid sequence represented by SEQ ID NO:123. The present invention further pertains to the peptides encoded by said polynucleotides. The present invention further pertains to CD4+ T cells into which TCR genes that contain said polynucleotides have been introduced, the induction of WT1-specific cytotoxic T lymphocytes (CTLs) using the CD4+ T cells, the treatment of cancer, etc.
