The Ohio State Innovation Foundation;Akebia Therapeutics, inc.
发明人:
Clay B. Marsh,Timothy Darren Eubank,Julie Michelle Roda,Robert Shalwitz
申请号：
US15154317
公开号：
US20170105981A1
申请日:
2016.05.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed herein is {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino} acetic acid and the ester and amide prodrugs thereof, that can stabilize hypoxia inducible factor-2 alpha (HIF-2α) and thereby provide a method for treating cancer. Further disclosed are compositions which comprise {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino} acetic acid and/or a prodrug thereof which can be used to treat cancer.
