NOGUERA, IRENE,THURSTON, GAVIN,GALE, NICHOLAS,SMITH, ERIC
申请号：
PL06848586
公开号：
PL1962895T3
申请日:
2006.12.15
申请国别(地区):
PL
年份:
2013
代理人:
摘要：
A therapeutic method for inhibiting tumor development or growth, comprising administering an agent capable of inhibiting human delta-like ligand 4 (DII4) activity to a subject in need thereof. In one embodiment, the agent is an anti-DII4 antibody or antibody fragment capable of inhibiting the binding of DII4 to a Notch receptor. In another embodiment, the agent is a fusion protein comprising the extracellular domain of DII4 or a fragment or variant thereof, fused to a multimerizing component such as an Fc domain. The method of the invention is useful for inhibiting tumor growth, particularly in tumors which are not responsive to other therapeutic agents.
