A method for reducing inflammation at a site of injury in a mammal. A composition with an effective amount of pomegranate extract is administered to a mammal. The pomegranate extract is derived from at least one pomegranate solid and with a higher ratio of higher molecular weight polyphenols than is found in pomegranate juice substantially obtained from pomegranate arils. The effective amount is suitable to promote healing at a site of injury in said mammal.