SUGA MAMORU,須賀 守,KAYANO KOHEI,茅野 紘平,ISE MICHITAKA,伊勢 道隆
申请号：
JP2014056731
公开号：
JP2017088496A
申请日:
2014.03.19
申请国别(地区):
JP
年份:
2017
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide skin external preparations, such as pharmaceuticals, quasi drugs (for example, an ointment) and cosmetics which are effective in progressive inhibition of various disorders of the skin promoted by skin aging associated with aging or by exposure to ultraviolet light, are more stable, and are excellent in anti-oxidant effect and in anti-inflammatory effect.SOLUTION: A skin external preparation contains a main agent and a chromanol derivative represented by the following general formula (1). (Where, Rto Reach independently represent a hydrogen atom, a hydroxyl group, an alkyl group having 1 to 12 carbon atoms or an alkenyl group having 2 to 12 carbon atoms； and at least one of Rto Rrepresents a hydroxyl group.)SELECTED DRAWING: None【課題】加齢に伴う皮膚の老化や紫外線暴露により促進される皮膚の様々な障害の進行阻止に有効な皮膚外用剤であって、より安定で、かつ、抗酸化作用および抗炎症効果に優れる医薬品、医薬部外品（例えば軟膏剤）および化粧料等の皮膚外用剤を提供する。【解決手段】主剤、および下記一般式（１）で表されるクロマノール誘導体を含有する皮膚外用剤。（式中、Ｒ１～Ｒ１０は、それぞれ独立して、水素原子、ヒドロキシル基、炭素数が１～１２のアルキル基または炭素数が２～１２のアルケニル基を示し、Ｒ１～Ｒ１０のうち少なくとも１つはヒドロキシル基を示す。）【選択図】なし
