The present invention specifically recognizes and binds to the amino acid sequence of human FOLR1 or its three-dimensional structure for diseases involving human FOLR1-expressing cells, and further includes antibody-dependent cytotoxic activity (ADCC activity) and the like. An anti-human FOLR1 antibody having high effector activity is provided. The present invention specifically recognizes and binds to the amino acid sequence of human FOLR1 or its three-dimensional structure, and further has a ADCC activity and a CDC activity, or the antibody fragment thereof, a DNA encoding the antibody, and the DNA A vector containing the same, a transformant obtained by introducing the vector, a method for producing the antibody or the antibody fragment using the transformant, and a therapeutic agent and a diagnostic agent containing the antibody or the antibody fragment as an active ingredient can do.本発明は、ヒトＦＯＬＲ１発現細胞が関与する疾患に対して、ヒトＦＯＬＲ１のアミノ酸配列、又はその立体構造を特異的に認識し、かつ結合し、さらに抗体依存的細胞傷害活性（ＡＤＣＣ活性）などのエフェクター活性が高い抗ヒトＦＯＬＲ１抗体を提供する。本発明は、ヒトＦＯＬＲ１のアミノ酸配列、又はその立体構造を特異的に認識し、かつ結合し、さらにＡＤＣＣ活性及びＣＤＣ活性を有するモノクローナル抗体又は該抗体断片、該抗体をコードするＤＮＡ、該ＤＮＡを含むベクター、該ベクターを導入して得られる形質転換体、該形質転換体を用いる該抗体又は該抗体断片の製造方法、該抗体又は該抗体断片を有効成分とする、治療薬及び診断薬を提供することができる。
