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A method of vaccination or immunisation involving the use of a photosensitizing agent, an antigenic molecule and a tlr ligand
专利权人:
PCI BIOTECH AS
发明人:
HØGSET ANDERS,PAL JOHANSEN
申请号:
NZ62964414
公开号:
NZ629644A
申请日:
2014.08.28
申请国别(地区):
NZ
年份:
2016
代理人:
摘要:
Disclosed is a method of expressing an antigenic molecule or a part thereof on the surface of a cell, comprising contacting said cell with said antigenic molecule, a photosensitising agent, and a Toll-like receptor (TLR) ligand, and irradiating the cell with light of a wavelength effective to activate the photosensitising agent, wherein said antigenic molecule is released into the cytosol of the cell and the antigenic molecule or a part thereof is subsequently presented on the cell’s surface, wherein said method is performed in vitro, ex vivo or in a non-human animal in vivo. Also disclosed is the use of such cells in the manufacture of a medicament for stimulating an immune response in a subject.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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