Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimers disease, type 2 diabetes and parkinsons disease
Alan D Snow,Beth Nguyen,Gerardo Castillo,Virginia Sanders,Thomas Lake,Lesley Larsen,Rex T Weavers,Stephen Lorimer,David Larsen,David L Coffen
申请号：
US12837721
公开号：
US08163957B2
申请日:
2010.07.16
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimers disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinsons disease, and the manufacture of medicaments for such treatment.
